The chicken acid-sensing ion channel ASIC1 has been crystallized as a homotrimer.We address here the oligomeric state of the functional ASIC1 in situ at the cell surface.The oligomeric states of functional ASIC1a and mutants with additional cysteines introduced in the extracellular pore vestibule were resolved on Kids Swim Hats SDS-PAGE.The functio
Scraped surface heat exchangers (SSHEs) have prominently shown their eminence in various food, chemical and in pharmaceutical industries when the regular processing of fluids and pertinent materials is encountered.The heat transfer analysis of Williamson fluid flow with electro osmotic effects in a narrow-gap SSHE is designed by implementing consta
Abstract Background The incidence of cervical cancer in Kenya is among the highest in the world.Few Kenyan women are able to access screening, thus fueling the high cervical cancer burden.Self-collected human papilloma Virus (HPV) tests, administered during community-health campaigns in rural areas may be a way to expand access to screening.Methods
Leishmania infantum is the vector-borne trypanosomatid parasite causing visceral leishmaniasis in the Mediterranean basin.This neglected tropical disease is treated with a limited number of obsolete drugs that are not exempt from adverse effects and whose overuse has promoted the emergence of resistant pathogens.In the search for novel antitrypanos
A preformulative study was conducted to produce and characterize ethosomes for the transdermal delivery of gossypin.This plant-derived compound possesses many pharmacological properties, including antitumoral potential.Ethosome dispersions were designed as transdermal delivery systems for gossypin, employing two different production procedures.The